Effect of repetitive TMS and fluoxetine on cognitive function in patients with Parkinson's disease and concurrent depression
Identifieur interne : 001501 ( Main/Exploration ); précédent : 001500; suivant : 001502Effect of repetitive TMS and fluoxetine on cognitive function in patients with Parkinson's disease and concurrent depression
Auteurs : Paulo S. Boggio [Brésil] ; Felipe Fregni [États-Unis] ; Felix Bermpohl [États-Unis] ; Carlos G. Mansur [Brésil] ; Moacyr Rosa [Brésil] ; Demetrio O. Rumi [Brésil] ; Egberto R. Barbosa [Brésil] ; Marina Odebrecht Rosa [Brésil] ; Alvaro Pascual-Leone [États-Unis] ; Sérgio Paulo Rigonatti [Brésil] ; Marco A. Marcolin [Brésil] ; Maria Teresa Araujo Silva [Brésil]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-09.
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Abstract
Previous studies show that cognitive functions are more impaired in patients with Parkinson's disease (PD) and depression than in nondepressed PD patients. We compared the cognitive effects of two types of antidepressant treatments in PD patients: fluoxetine (20 mg/day) versus repetitive transcranial magnetic stimulation (rTMS, 15 Hz, 110% above motor threshold, 10 daily sessions) of the left dorsolateral prefrontal cortex. Twenty‐five patients with PD and depression were randomly assigned either to Group 1 (active rTMS and placebo medication) or to Group 2 (sham rTMS and fluoxetine). A neuropsychological battery was assessed by a rater blind to treatment arm at baseline and 2 and 8 weeks after treatment. Patients in both groups had a significant improvement of Stroop (colored words and interference card) and Hooper and Wisconsin (perseverative errors) test performances after both treatments. Furthermore, there were no adverse effects after either rTMS or fluoxetine in any neuropsychological test of the cognitive test battery. The results show that rTMS could improve some aspects of cognition in PD patients similar to that of fluoxetine. The mechanisms for this cognitive improvement are unclear, but it is in the context of mood improvement. © 2005 Movement Disorder Society
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DOI: 10.1002/mds.20508
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-09">2005-09</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1178">1178</biblScope><biblScope unit="page" to="1184">1184</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">9253071EFCB1E9FC4C5041F83F9713C49AA3775B</idno><idno type="DOI">10.1002/mds.20508</idno><idno type="ArticleID">MDS20508</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cognition</term><term>depression</term><term>fluoxetine</term><term>neuropsychological assessment</term><term>transcranial magnetic stimulation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous studies show that cognitive functions are more impaired in patients with Parkinson's disease (PD) and depression than in nondepressed PD patients. We compared the cognitive effects of two types of antidepressant treatments in PD patients: fluoxetine (20 mg/day) versus repetitive transcranial magnetic stimulation (rTMS, 15 Hz, 110% above motor threshold, 10 daily sessions) of the left dorsolateral prefrontal cortex. Twenty‐five patients with PD and depression were randomly assigned either to Group 1 (active rTMS and placebo medication) or to Group 2 (sham rTMS and fluoxetine). A neuropsychological battery was assessed by a rater blind to treatment arm at baseline and 2 and 8 weeks after treatment. Patients in both groups had a significant improvement of Stroop (colored words and interference card) and Hooper and Wisconsin (perseverative errors) test performances after both treatments. Furthermore, there were no adverse effects after either rTMS or fluoxetine in any neuropsychological test of the cognitive test battery. The results show that rTMS could improve some aspects of cognition in PD patients similar to that of fluoxetine. The mechanisms for this cognitive improvement are unclear, but it is in the context of mood improvement. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Brésil</li><li>États-Unis</li></country><region><li>Massachusetts</li><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><country name="Brésil"><region name="État de São Paulo"><name sortKey="Boggio, Paulo S" sort="Boggio, Paulo S" uniqKey="Boggio P" first="Paulo S." last="Boggio">Paulo S. Boggio</name></region><name sortKey="Araujo Silva, Maria Teresa" sort="Araujo Silva, Maria Teresa" uniqKey="Araujo Silva M" first="Maria Teresa" last="Araujo Silva">Maria Teresa Araujo Silva</name><name sortKey="Barbosa, Egberto R" sort="Barbosa, Egberto R" uniqKey="Barbosa E" first="Egberto R." last="Barbosa">Egberto R. Barbosa</name><name sortKey="Mansur, Carlos G" sort="Mansur, Carlos G" uniqKey="Mansur C" first="Carlos G." last="Mansur">Carlos G. Mansur</name><name sortKey="Marcolin, Marco A" sort="Marcolin, Marco A" uniqKey="Marcolin M" first="Marco A." last="Marcolin">Marco A. Marcolin</name><name sortKey="Odebrecht Rosa, Marina" sort="Odebrecht Rosa, Marina" uniqKey="Odebrecht Rosa M" first="Marina" last="Odebrecht Rosa">Marina Odebrecht Rosa</name><name sortKey="Rigonatti, Sergio Paulo" sort="Rigonatti, Sergio Paulo" uniqKey="Rigonatti S" first="Sérgio Paulo" last="Rigonatti">Sérgio Paulo Rigonatti</name><name sortKey="Rosa, Moacyr" sort="Rosa, Moacyr" uniqKey="Rosa M" first="Moacyr" last="Rosa">Moacyr Rosa</name><name sortKey="Rumi, Demetrio O" sort="Rumi, Demetrio O" uniqKey="Rumi D" first="Demetrio O." last="Rumi">Demetrio O. Rumi</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Fregni, Felipe" sort="Fregni, Felipe" uniqKey="Fregni F" first="Felipe" last="Fregni">Felipe Fregni</name></region><name sortKey="Bermpohl, Felix" sort="Bermpohl, Felix" uniqKey="Bermpohl F" first="Felix" last="Bermpohl">Felix Bermpohl</name><name sortKey="Pascual Eone, Alvaro" sort="Pascual Eone, Alvaro" uniqKey="Pascual Eone A" first="Alvaro" last="Pascual-Leone">Alvaro Pascual-Leone</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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